Mechanistic Insights into Hypoxia
Our laboratory investigates how oxygen deprivation within the tumor microenvironment drives cancer progression, metastasis, and therapy resistance. We focus on elucidating molecular mechanisms, particularly hypoxia-induced signaling pathways, to identify novel therapeutic targets. Our mission is to bridge basic science with translational research, developing innovative strategies to achieve more effective and precise cancer treatments.
Engineering EVs for Targeted Therapeutic Delivery
Extracellular vesicles (EVs) are nanoscale, membrane-bound particles that carry proteins, nucleic acids, lipids, and metabolites. Secreted by nearly all cell types, they play a critical role in intercellular communication. Owing to their intrinsic capacity to encapsulate and deliver bioactive molecules, EVs have emerged as promising vehicles for therapeutic applications. Our research is dedicated to engineering EVs into efficient delivery systems for targeted therapies.